FORMULATION AND EVALUATION OF LOTION AND CREAM OF NANOSIZED CHITOSAN-MANGOSTEEN (Garcinia mangostana L.) PERICARP EXTRACT

Nanosized chitosan-mangosteen pericarp extract has antiacne activity against Pseudomonas acnes. This study aimed to formulate and evaluate of lotions and creams of nanosized mangosteen pericarp extract. Lotions were formulated with various suspending agents, i.e. xanthan gum, carboxymethylcellulose, and bentonite magma. Creams were formulated with various ingredients of the oil phase, i.e. adeps lanae, liquid paraffin, and glycerin. Evaluation of lotions and creams for six-week observation includes organoleptic characteristics, homogeneity, pH, viscosity, irritancy test, and a preference test. Data were shown as mean and standard deviation, then statistically analyzed using one-way analysis of variance. The results were showing that the mangosteen pericarp extract can be prepared as a nanosized particle, then formulated as lotions and creams with various formulas. All lotions and creams met the requirements and non-irritating. FC3 was the most preferred formula.