SYNTHESIS OF SOME CHALCONE DERIVATIVES, IN VITRO AND IN SILICO TOXICITY EVALUATION | Zendy

Alfinda Novi Kristanti | Zendy; H. Suwito | Zendy; Nanik Siti Aminah | Zendy; Kautsar Ul Haq | Zendy; Helda Dwi Hardiyanti | Zendy; Hesty Anggraeni | Zendy; Nahda Aqila Faiza | Zendy; R.S. Anto | Zendy; Siti Muharromah | Zendy

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SYNTHESIS OF SOME CHALCONE DERIVATIVES, IN VITRO AND IN SILICO TOXICITY EVALUATION

Author(s) -

Alfinda Novi Kristanti,

H. Suwito,

Nanik Siti Aminah,

Kautsar Ul Haq,

Helda Dwi Hardiyanti,

Hesty Anggraeni,

Nahda Aqila Faiza,

R.S. Anto,

Siti Muharromah

Publication year - 2020

Publication title -

rasayan journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.281

H-Index - 22

eISSN - 0976-0083

pISSN - 0974-1496

DOI - 10.31788/rjc.2020.1315534

Subject(s) - chalcone , in silico , in vitro , toxicity , chemistry , pharmacology , combinatorial chemistry , toxicology , computational biology , stereochemistry , biology , biochemistry , organic chemistry , gene

Chalcone can be synthesized using some methods, but conventional Claisen-Schmidt condensation is still the best method. The objevtives of this study were to synthesize some chalcone derivatives using conventional ClaisenSchmidt condensation by reacting 2-hydroxyacetophenone and some substituted benzaldehydes using NaOH 40%, followed by evaluating their cytotoxicity in vitro against HeLa cancer cells line using MTT method and analyzing molecular docking on p53 and MDM2 interaction. Cytotoxicity test exhibited that 2,5-dimethoxy-2 ́hydroxychalcone and 4-chloro-2'-hydroxychalcone gave very low IC50, but both did not show potential apoptosis activity, while in docking analysis 4-chloro-2'-hydroxychalcone showing the best results.

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