SYNTHESIS, MOLECULAR DOCKING AND ANTITUBERCULAR ACTIVITY OF NEW BI HETEROCYCLIC COMPOUNDS ON BENZIMIDAZOLE MOIETY | Zendy

Dhanaja Kotte | Zendy; Kumaraswamy Gullapelli | Zendy; Ravichandar Maroju | Zendy; Ramchander Merugu | Zendy; Brahmeshwari Gavaji | Zendy

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SYNTHESIS, MOLECULAR DOCKING AND ANTITUBERCULAR ACTIVITY OF NEW BI HETEROCYCLIC COMPOUNDS ON BENZIMIDAZOLE MOIETY

Author(s) -

Dhanaja Kotte,

Kumaraswamy Gullapelli,

Ravichandar Maroju,

Ramchander Merugu,

Brahmeshwari Gavaji

Publication year - 2020

Publication title -

rasayan journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.281

H-Index - 22

eISSN - 0976-0083

pISSN - 0974-1496

DOI - 10.31788/rjc.2020.1315465

Subject(s) - benzimidazole , moiety , docking (animal) , combinatorial chemistry , chemistry , stereochemistry , organic chemistry , medicine , nursing

A series of new and efficient Benzo [d] imidazole-2-yl -3, 5 substituted diphenyl -3,3a.5.6 –Tetrahydro 2H-pyrazole thiazole derivatives (4a-j) were synthesized from Schiff base derivatives of thiazolidinediones (3a-j) using hydrazine hydrate. The synthesized compounds were screened for their antitubercular and molecular docking studies. The results of docking studies are supporting antitubercular activity showing high inhibition constant and binding energy. The structures of synthesized compounds were characterized by IR, HNMR, Mass spectroscopic methods.

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