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A series of new and efficient Benzo [d] imidazole-2-yl -3, 5 substituted diphenyl -3,3a.5.6 –Tetrahydro 2H-pyrazole thiazole derivatives (4a-j) were synthesized from Schiff base derivatives of thiazolidinediones (3a-j) using hydrazine hydrate. The synthesized compounds were screened for their antitubercular and molecular docking studies. The results of docking studies are supporting antitubercular activity showing high inhibition constant and binding energy. The structures of synthesized compounds were characterized by IR, HNMR, Mass spectroscopic methods.

SYNTHESIS, MOLECULAR DOCKING AND ANTITUBERCULAR ACTIVITY OF NEW BI HETEROCYCLIC COMPOUNDS ON BENZIMIDAZOLE MOIETY