UPDATES ON 4-HYDROXYDERRICIN AND XANTHOANGELOL OF ANGELICA PLANTS: EXTRACTION AND PHARMACOLOGICAL ACTIVITIES

Two chalcones, e.g. 4-hydroxyderricin and xanthoangelol, have been proven in revealing many potential pharmacological activities, therefore their extraction method is critical because it influences the yield and, furthermore, its pharmacological activities. This review highlights the extraction method and various pharmacological activities of 4-hydroxyderricin and xanthoangelol from Angelica keiskei plants. The chalcone’s diverse pharmacological activities are attributed to the flexible conformation of the opened-C ring and the moderate lipophilicity character on the A aromatic ring. The presence of a double bond in conjugation with carbonyl moiety is also important. However, further explorations need to be performed to obtain a remarkable yield of these particular prenylated-compounds and to understand their mechanisms of actions.