SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL ACTIVITY OF NEW NICOTINAMIDE-THIAZOLE DERIVATIVES

In this era, the identification or synthesis of a new antibiotic is important research due to the pollution and harmful bacterial pathogens. Hence this work selected the already known mild active molecules such as Nicotinamide and Thiazole to enhance the activity against the disease-causing pathogens. Using peptide coupling reagent EDCI, nine compounds were prepared and characterized by 1 H NMR, Mass spectroscopy. The characterized compounds were evaluated In vitro antibacterial and antifungal activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumonia, Candida albicans by broth dilution method and zone of inhibition measured in millimeter. All the derivatives showed good to moderate activity. Out of nine compounds N-(4-(thiomorpholine4-carbonyl) thiazol-2-yl) nicotinamide showed better zone of inhibition between 27 mm and 34 mm. the outcomes of the result revealed that the diamide bond acts as an important pharmacophore and exposed the good inhibition behavior.