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Performance characterization four types of Molecular Imprinted Polymer (MIP) atenolol has been carried out with two different types of porogens(butanol and propanol) and polymerization methods (bulk and precipitation). Four polymers were optimized and applied to the serum, results showed that the polymer made by the precipitation method in butanol solvents produced the best recovery value (74.64%) and have mesopore form based on pore size. Meanwhile, the results of physical characterization showed that there was no functional group change between sorbent before and after applied as SPE cartridges. Sorbent made by bulk method had better physical stability than sorbent made by the precipitation method.

PERFORMANCE EVALUATION OF ATENOLOL MOLECULAR IMPRINTED POLYMER USING TWO DIFFERENT POLYMERIZATION AND TWO DIFFERENT POROGEN