Open AccessCYTOTOXIC LACTONE-TYPE DITERPENOIDS AND TRITERPENOID FROM Vitex pubescens Vahl
Author(s) -
Lenny Anwar,
Adlis Santoni,
Deddi Prima Putra,
Mai Efdi
Publication year - 2019
Publication title -
rasayan journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.281
H-Index - 22
eISSN - 0976-0083
pISSN - 0974-1496
DOI - 10.31788/rjc.2019.1235025
Subject(s) - triterpenoid , traditional medicine , vitex , terpenoid , botany , chemistry , biology , medicine
The stem bark of V. pubescens Vahl has been used as a traditional medicine in Indonesia. Isolation of the stem bark of V. pubescens Vahl with some column chromatography techniques led to obtaining the lactone diterpenoids, neoandrographolide (1), andrographolide (2), 14-deoxyandrographolide (3), and a pentacyclic triterpenoid compound, betulinic acid (4). Neoandrographolide (1) was reported in this plant for the first time. Cytotoxic activity of compounds 1-4 showed inactivity against HeLa (MTT assay).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom