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Cefixime is used for bacterial infections recovery, Ornidazole is used as antibiotic for protozoan infections and Moxifloxacin is also an antibiotic for multiple bacterial infections. Accurate, simple and precise HPLC method was developed for the determination of Cefixime, Ornidazole and Moxifloxacin in the tablet pharmaceutical dosage form. The RP-HPLC method was developed and validated with precision, specificity, accuracy, ruggedness, robustness and linearity. Chromatographic conditions are mobile phase A: 6.8g KH2PO4 in 1000 ml water and mobile phase B: Acetonitrile, Agilent Zorbax SBC18, 100 x 4.6mm, 5μm, 280 nm, 1.0ml/min, 25 min (gradient program: mobile phase B at 0min 5%, 5min 5%, 10 min 15%, 14 min 15%, 17 min 35%, 20 min 5% and 25 min 5%. All validation results showed the accuracy results and % RSD for test area, %assay values were also within the limits. This HPLC method can be used to analyze the regular product quality control purpose.

STABILITY INDICATING HPLC METHOD FOR THE QUANTIFICATION OF CEFIXIME, ORNIDAZOLE AND MOXIFLOXACIN IN SOLID DOSAGE FORMS