PROSPECTS OF SKQ1 (10- (6'-PLASTOQUINOYL) DECYLTRIPHENYLPHOSPHONIUM) APPLICATION FOR PREVENTION OF ORAL CAVITY DISEASES

Background Dental infections, like dental degradation and periodontal diseases, are the most widespread bacterial infections in humans. Due to non-life threatening nature and ubiquity, their significance in healthcare was minimized. Still, they burden the economics of healthcare and the patients. Material and methods The study of SkQ1 (10-(6'-plastoquinoyl) decyltriphenylphosphonium) antibacterial activity against Streptococcus mutans species and dental biofilm bacteria was conducted. Bactericidal and bacteriostatic effect of this substance in micromolar concentrations on pure cultures and in higher concentrations on dental plaque bacteria was established. The compound binding effect with high molecular components of human saliva was identified and quantitatively evaluated. Results The test results showed that acidic media or competing for cation-containing drugs weaken this effect. SkQ1 is potentially applicable for oral cavity infections treatment and its efficiency can be enhanced by the utilization of proper vehicles. Conclusions SkQ1 disturbs bacteria transmembrane potential, so it can be considered as an antibacterial agent that is effective against gram-positive bacteria and can increase gram-negative bacteria sensitivity to the compounds that they are often resistant to.