SYNTHESIS AND CHARACTERIZATION OF SCHIFF BASE SUBSTITUTED CARBAZOLE BEARING PYRIDOPYRIMIDINE COMPOUNDS

The Schiff bases formation which is useful molecules both biologically and synthetically is one of the most important reactions in organic and medicinal chemistry. Available materials, catalyst-free and mild reaction conditions are essential to synthesize the Schiff bases in a good yield. In basic conditions, Schiff base substituted carbazole bearing pyridopyrimidine compounds (4a-n) were efficiently synthesized through corresponding benzaldehyde derivatives on treatment with 7(4-amino-phenyl)-5-(9-ethyl-9H-carbazol-3-yl)1,3-dimethyl1Hpyrido [2,3-d] pyrimidine-2,4-dione in tetrahydrofuran under reflux in good yields. The structures of the synthesized compounds were identified by IR, H NMR and C NMR and elemental analysis.