MICROWAVE ASSISTED SYNTHESIS, ANTIMICROBIAL ACTIVITY AND IN SILICO PHARMACOKINETIC STUDY OF SOME NOVEL 1', 3', 4'-OXADIAZOLE DERIVATIVES

A novel series of 1', 3’, 4’ -oxadiazole derivatives were synthesized. The chemical structure of the synthesized compounds was established on the basis of spectral data and elemental analysis. Further, the synthesized compounds were tested for their antimicrobial activity by disk diffusion assay. The synthesized compounds exhibited significant activity against selected bacterial and fungal strains compared to the standard drugs. Lipinski's rule and in silico ADMET pharmacokinetic parameters were found to be within the acceptable range thereby indicating their potential as a drug-like molecule. Compounds 4c and 4d showed good drug-likeness score and bioactivity score, in comparison with the other compounds. The SAR study revealed that the hydroxy/chloro substituent at the para position of the phenyl ring on oxadiazole ring can improve the antimicrobial activity.