SYNTHESIS, CHARACTERIZATION AND EVALUATION OF ANTI-MICROBIAL ACTIVITY OF NOVEL SUBSTITUTED QUINAZOLINE DERIVATIVES

A series of novel substituted 8-bromo-2-(dimethylamino)-3-(3-(dimethylamino) propyl) quinazoline-4(3H)-one derivatives 2(a-h) were prepared with excellent yields and evaluate their antimicrobial activity. These compounds 2(a-h) are prepared the by the reactions between 8-bromo-3-(2-(dimethylamino) ethyl)-2-(methylthio) quinazoline4(3H)-one and secondary amines. These all compounds characterization done by different spectroscopic methods PMR, IR, CMR, Mass Spectral and elemental data. All compounds were evaluated for their biological activity i.e., antibacterial and anti-fungal activity. The anti-bacterial activities were evaluated in vitro method. The antibacterial activity 8-bromo-2-(dimethylamino)-3-(3-(dimethylamino) propyl) quinazoline-4(3H)-one derivatives 2(a-h) was assessed against three representative Gram-positive bacteria viz. Bacillus subtilis, Bacillus sphaericus and Staphylococcus aureus, and three Gram-negative bacteria viz. Pseudomonas aeruginosa, Klebsiella aerogenes and Chromobacterium violaceum, and antifungal activity against Candida albicans, Aspergillus fumigates, Trichophyton rubrum and Trichophyton mentagrophytes. Among all these compounds most of the compounds were exhibit more potent anti-bacterial and anti-fungal activity against standard drugs.