EFFECT OF DIFFERENT POLYMER AND OLEIC ACID ENCHANCER IN NIFEDIPINE MATRIX TRANSDERMAL PATCH FORMULATION AND EVALUATION

Nifedipine is an antihypertensive drug that has acted as a calcium channel antagonist. Nifedipine has a short tand hence its oral use should be in a more frequent frequency. This will affect the patient's compliance in taking the drug. To overcome this problem, the transdermal route drug delivery system can be an alternative.This study aims to find out the effect of the different polymer and the oleic acid enhancer on the characteristic of matrix transdermal patch. The patch was made in six formulas comprising polymer combination of ES-PVP (F1, F2, F3) and ES-HPMC (F4, F5, F6). The patch is formulated with solvent evaporation techniques. The dried patch was then evaluated for its physicochemical characteristics evaluation and in vitro release profile. The characteristic test result shows that the nefedipine patch is yellow, odorless and flat surface. The thickness is between 0.0196 ± 0.0001cm to 0.0003 ± 0.0003 cm. Uniformity of weight is between 91.16 ± 0.26 mg to 95.16 ± 0.12 mg. % moisture content is between 1.1068 ± 0.5849% to 4.8602 ± 0.4255%. Drug content 96.90 ± 1.83% to 99.38 ± 0.22%. The drug release follows the Higuchi order. The highest penetration result was found in formula 6 with a polymer composition of ES:HPMC (16.25 mg: 48.75 mg) of 88.77% for 24 hours. From this study it can be concluded that the 6 formula is the best which can be observed from its physicochemical characteristics and in vitro release profile.