Stereotactic transplantation of a dopamine-producing capsule into the striatum for treatment of Parkinson disease: a preclinical primate study | Zendy

Hideyuki Yoshida | Zendy; Isao Date | Zendy; Tetsuro Shingo | Zendy; Kenjiro Fujiwara | Zendy; Kazuki Kobayashi | Zendy; Yasuyuki Miyoshi | Zendy; Takashi Ohmoto | Zendy

Open Access

Stereotactic transplantation of a dopamine-producing capsule into the striatum for treatment of Parkinson disease: a preclinical primate study

Author(s) -

Hideyuki Yoshida,

Isao Date,

Tetsuro Shingo,

Kenjiro Fujiwara,

Kazuki Kobayashi,

Yasuyuki Miyoshi,

Takashi Ohmoto

Publication year - 2003

Publication title -

journal of neurosurgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.564

H-Index - 210

eISSN - 1933-0693

pISSN - 0022-3085

DOI - 10.3171/jns.2003.98.4.0874

Subject(s) - dopamine , transplantation , striatum , medicine , levodopa , parkinson's disease , capsule , pathology , disease , biology , botany

The PC12 cells are well known for their ability to secrete dopamine and levodopa. In multiple animal mode encapsulated PC12 cells have been shown to ameliorate parkinsonian symptoms when transplanted into the striatum; technique is expected to be effective clinically as well. The present study was performed using nonhuman primates to ensure that the transplantation of encapsulated PC12 cells is likely to be both safe and effective in human clinical trials.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research