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Hypertension is the most important risk factor for worldwide morbidity and mortality and a major public health problem which affects 20% of the adult population, responsible for over 70% of stroke in women and 40% in men and the single most important persuasive threat issue for stroke.[1-4] Hypertension is one of the major mainsprings which contributes to disability, health care costs, and stroke mortality[5,6] and one of the major but preventable or controllable risk factors for stroke. Low adherence to antihypertensive therapy is found to be associated with uncontrollable hypertension.[7] The most common neurological disease “Stroke” is not a medical jargon for the layman in the present scenario. Being the second cause of death due to non-communicable disease, stroke is a major health problem in many countries.[8-10] Stroke, a feasible outcome of hypertension, often leads to death and Impact of Non-compliance with Antihypertensive Management on Development of Stroke among Hypertensive Patients: A Case–Control Study