Refin-Align: New Refinement Algorithm For Multiple Sequence Alignment | Zendy

Ahmed Mokaddem | Zendy; Amine Bel Hadj | Zendy; Mourad Elloumi | Zendy

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Refin-Align: New Refinement Algorithm For Multiple Sequence Alignment

Author(s) -

Ahmed Mokaddem,

Amine Bel Hadj,

Mourad Elloumi

Publication year - 2019

Publication title -

informatica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.172

H-Index - 34

eISSN - 1854-3871

pISSN - 0350-5596

DOI - 10.31449/inf.v43i4.2621

Subject(s) - sequence (biology) , algorithm , multiple sequence alignment , computer science , alignment free sequence analysis , block (permutation group theory) , sequence alignment , structural alignment , mathematics , peptide sequence , biochemistry , genetics , chemistry , geometry , gene , biology

In this paper, we present Refin-Align a new refinement algorithm for a multiple sequence alignment. Refining alignment consists on constructing a new more accurate multiple sequence alignment from an initial one by applying some modifications. Our refinement algorithm Refin-Align uses a new definition of block and also our multiple sequence alignment algorithm Pro-malign. We assess our algorithm Refin-Align on multiple sequence alignment constructed by different algorithms using different benchmarks of protein sequences. In the most cases treated, our algorithm improves the scores of the multiple sequence alignment.

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