SYNTHESIS OF DIVERSE TRACERS ON EWOD MICRODEVICE FOR POSITRON EMISSION TOMOGRAPHY (PET) | Zendy

S. Chen | Zendy; Rabia Javed | Zendy; Jia Lei | Zendy; H.-K. Kim | Zendy; Graciela Flores | Zendy; R. Michael van Dam | Zendy; Pei Yuin Keng | Zendy; C.-J. Kim | Zendy

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SYNTHESIS OF DIVERSE TRACERS ON EWOD MICRODEVICE FOR POSITRON EMISSION TOMOGRAPHY (PET)

Author(s) -

S. Chen,

Rabia Javed,

Jia Lei,

H.-K. Kim,

Graciela Flores,

R. Michael van Dam,

Pei Yuin Keng,

C.-J. Kim

Publication year - 2012

Publication title -

1998 solid-state, actuators, and microsystems workshop technical digest

Language(s) - English

Resource type - Conference proceedings

DOI - 10.31438/trf.hh2012.50

Subject(s) - positron emission tomography , microfluidics , electrowetting , materials science , tracer , biosensor , tomography , nanotechnology , dielectric , optoelectronics , optics , physics , nuclear medicine , nuclear physics , medicine

We demonstrate the synthesis of diverse tracers (sugar, DNA nucleoside, protein labeling compound, and neurotransmitter) using a single electrowetting-on-dielectric (EWOD) chip design with multifunctional electrodes for heating, temperature sensing, and EWOD driving. Furthermore, we present a key advantage of microfluidic chemical synthesis in increasing specific activity (radioactivity per mass of tracer) compared to macroscale synthesis. These are important steps toward more affordable, specific, and universal tracer production for use in positron emission tomography (PET).

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