Superiority of PCR against microscopy for diagnosing Entamoeba histolytica in liver abscess samples | Zendy

Muhammad Morshed | Zendy; Sarah Cherian | Zendy; Teresa Lo | Zendy; Min-Kuang Lee | Zendy; Quantine Wong | Zendy; Linda Hoang | Zendy

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Superiority of PCR against microscopy for diagnosing Entamoeba histolytica in liver abscess samples

Author(s) -

Muhammad Morshed,

Sarah Cherian,

Teresa Lo,

Min-Kuang Lee,

Quantine Wong,

Linda Hoang

Publication year - 2018

Publication title -

journal of the association of medical microbiology and infectious disease canada

Language(s) - English

Resource type - Journals

ISSN - 2371-0888

DOI - 10.3138/jammi.2.2.01

Subject(s) - entamoeba histolytica , serology , liver abscess , polymerase chain reaction , amoebic liver abscess , microscopy , biology , pathology , microbiology and biotechnology , abscess , medicine , immunology , gene , antibody , biochemistry , genetics

A total of 25 amoebic liver abscess (ALA) samples were assessed by microscopy, serology, and polymerase chain reaction (PCR). While microscopy was negative for Entamoeba histolytica in all samples, DNA was amplified in 11 samples and had 100% compliance with serology. In conclusion, PCR proved to be a more sensitive and specific test for acute ALA infection caused by E. histolytica and should be used as a supplemental test for microscopy-negative liver abscess samples.

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