Open AccessExpression of transforming growth factor-β1 and connective tissue growth factor in the capsule in a rat immobilized knee model
Author(s) -
Yoshihiro Hagiwara,
E. Chimoto,
P. Ichiro Takahashi,
Akira Andõ,
Yasuyuki Sasano,
Eiji Itoi
Publication year - 2008
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/2000-1967-223
Subject(s) - medicine , transforming growth factor , capsule , growth factor , connective tissue , microbiology and biotechnology , pathology , receptor , botany , biology
Contracture is a very common complication of joint immobilization in daily examination, but its cause is still unknown. A fibrotic change of the capsule is suggested to be one of the main causes of the joint contracture. The goal of this study was to analyze the expression pattern of transforming growth factor-beta1 (TGF-beta1) and connective tissue growth factor (CTGF), which are implicated in fibrosis in the capsule of a rat immobilized knee model.