Experimental murine model of disseminated infection bySaksenaea vasiformis: successful treatment with posaconazole | Zendy

Valentina Salas | Zendy; Francisco Pastor | Zendy; Enrique Calvo | Zendy; Deanna A. Sutton | Zendy; Dea García-Hermoso | Zendy; Emilio Mayayo | Zendy; Françoise Dromer | Zendy; A W Fothergill | Zendy; Eduardo Álvarez | Zendy; Josep Guarro | Zendy

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Experimental murine model of disseminated infection bySaksenaea vasiformis: successful treatment with posaconazole

Author(s) -

Valentina Salas,

Francisco Pastor,

Enrique Calvo,

Deanna A. Sutton,

Dea García-Hermoso,

Emilio Mayayo,

Françoise Dromer,

A W Fothergill,

Eduardo Álvarez,

Josep Guarro

Publication year - 2012

Publication title -

medical mycology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.004

H-Index - 86

eISSN - 1460-2709

pISSN - 1369-3786

DOI - 10.3109/13693786.2012.673137

Subject(s) - posaconazole , amphotericin b , broth microdilution , microbiology and biotechnology , in vitro , biology , fungus , antifungal , medicine , antibiotics , minimum inhibitory concentration , biochemistry , botany

We have determined the in vitro activity of amphotericin B (AMB) and posaconazole (PSC) against Saksenaea vasiformis using broth microdilution and disk diffusion methods and determined the minimal fungicidal concentration (MFC). PSC was found to have the greatest in vitro activity in all cases and was the most efficacious in prolonging survival and reducing the fungal load in an immunocompetent murine model of disseminated infection caused by four strains of the fungus.

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