Development of murine models of disseminated infection byNeoscytalidium dimidiatum | Zendy

Mery Ruíz-Cendoya | Zendy; Hugo Madrid | Zendy; F. Javier Pastor | Zendy; Emilio Mayayo | Zendy; Marçal Mariné | Zendy; Josep Guarro | Zendy

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Development of murine models of disseminated infection byNeoscytalidium dimidiatum

Author(s) -

Mery Ruíz-Cendoya,

Hugo Madrid,

F. Javier Pastor,

Emilio Mayayo,

Marçal Mariné,

Josep Guarro

Publication year - 2010

Publication title -

medical mycology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.004

H-Index - 86

eISSN - 1460-2709

pISSN - 1369-3786

DOI - 10.3109/13693780903452917

Subject(s) - biology , inoculation , tail vein , immunocompetence , virulence , immunology , immune system , in vivo , microbiology and biotechnology , biochemistry , gene

We have developed two murine models of disseminated infections by Neoscytalidium dimidiatum, an emerging dematiaceous fungus. Immunosuppressed mice were challenged through the lateral tail vein with 1 x 10(5) or 1 x 10(6) CFU/ml and immunocompetent animals with 1 x 10(6) or 1 x 10(7) CFU/ml. N. dimidiatum var. dimidiatum was more virulent than the nonpigmented variety, N. dimidiatum var. hyalinum. All mice infected with N. dimidiatum var. dimidiatum died within 8 days while those infected with N. dimidiatum var. hyalinum survived to the end of the experiment. Fungal load in tissue was also higher in animals inoculated with N. dimidiatum var. dimidiatum. In general, of the five organs tested, spleens and kidneys were most affected.

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