The Effects of Tris(2,3-Dibromopropyl)Phosphate on the Reproductive System of Male Rats

Tris(2,3-dibromopropyl)phosphate (TRIS) administered intraperitoneally to adult, male Sprague-Dawley rats for 12 weeks at concentrations of 85.1 to 340.5 mg/week caused significant, dose-related declines in the weights of the testes, epididymides, and seminal vesicles. Sperm production by the testes and sperm storage in the epididymides were also reduced. Although prostate weight declined, the effect was not correlated with the dose of TRIS. Neither serum concentrations of testosterone nor the testicular capacity to produce testosterone in vitro were affected by any dose of TRIS.