Open AccessPerinatal Hypoadrenalism in the Rat does not Alter Glucose Tolerance and Insulin Secretory Response to Glucose
Author(s) -
Mats G. Karlsson,
Ulf J. Eriksson,
Ingemar Swenne
Publication year - 1990
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009739009178583
Subject(s) - medicine , metyrapone , endocrinology , insulin , corticosterone , insulin response , congenital adrenal hyperplasia , pregnancy , glucose tolerance test , carbohydrate metabolism , fetus , hormone , plasma glucose , insulin resistance , genetics , biology
Fetal and neonatal hypoadrenalism was induced by treating rat mothers with metyrapone from day 12 of pregnancy to day 7 postnatally. Hypoadrenalism in the neonates was indicated by a slight reduction in body weight, adrenal hyperplasia and a tendency towards reduced adrenal corticosterone concentration. An intraperitoneal glucose tolerance test on the 7-day old neonates did not show any disturbancies of glucose disposal or insulin secretory response to glucose. The data suggest that adrenal corticosteroids are not essential for the perinatal development of the B-cell secretory response to glucose.