Open AccessRadioprotection of the Kidney with Degradable Microspheres
Author(s) -
Ronald F. Tuma,
J. O. Forsberg,
S. Graffman,
B. Jung,
Peter R. Lynch
Publication year - 1985
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009738509178482
Subject(s) - medicine , kidney , microsphere , urology , renal artery , creatinine , irradiation , nuclear medicine , physics , chemical engineering , nuclear physics , engineering
The left kidney of 9 dogs was irradiated daily for three days with 300 kVp X-rays. Radioprotection was attempted in 5 of the kidneys by administration of degradable microspheres in the renal artery, immediately before irradiation. Protected kidneys received 3 X 8 or 3 X 12 Gy in midplane dose, unprotected kidneys 3 X 5.2 or 3 X 8 Gy. A protective effect due to induced hypoxia could be demonstrated in creatinine clearance, which was significantly higher in protected than in unprotected kidneys at 7 - 13 weeks after irradiation.