Open AccessA case of metachronous double primary neuroendocrine cancer in pancreas/ileum and uterine cervix
Author(s) -
Giovanni Sisti,
Anna Maria Buccoliero,
Luca Novelli,
Maddalena Sansovini,
Stefano Severi,
Annalisa Pieralli,
Lorenzo Livi,
Massimiliano Fambrini
Publication year - 2012
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009734.2012.707254
Subject(s) - medicine , uterine cervix , gynecology , ileum , primary cancer , pancreas , oncology , cancer , gastroenterology , carcinoma
We describe an unusual case of a 50-year-old female patient developing two primary cancers with neuroendocrine features. Initially the patient underwent surgery for an entero-pancreatic neuroendocrine carcinoma. During the subsequent follow-up she experienced some episodes of vaginal bleeding with negative PET scanning with the tracer fluorine-18 (F-18) fluorodeoxyglucose (FDG). A Papanicolaou (pap) smear and an endometrial biopsy revealed a primary neuroendocrine cancer of the uterine cervix. The present case underlines the importance of clinical follow-up after a diagnosis of intestinal neuroendocrine tumor, investigating any new symptom. Female patients, after the diagnosis of entero-pancreatic neuroendocrine carcinoma, must be recommended to continue screening pap test examinations for the likelihood of classical squamous and glandular cervical cancers and also for neuroendocrine cervical cancer.