Myc proteins in brain tumor development and maintenance | Zendy

Fredrik J. Swartling | Zendy

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Myc proteins in brain tumor development and maintenance

Author(s) -

Fredrik J. Swartling

Publication year - 2012

Publication title -

upsala journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.808

H-Index - 41

eISSN - 2000-1967

pISSN - 0300-9734

DOI - 10.3109/03009734.2012.658975

Subject(s) - medulloblastoma , medicine , cancer research , glioma , transcription factor , brain tumor , bioinformatics , neuroscience , pathology , gene , genetics , biology

Myc proteins are often deregulated in human brain tumors, especially in embryonal tumors that affect children. Many observations have shown how alterations of these pleiotropic Myc transcription factors provide initiation, maintenance, or progression of tumors. This review will focus on the role of Myc family members (particularly c-myc and Mycn) in tumors like medulloblastoma and glioma and will further discuss how to target stabilization of these proteins for future brain tumor therapies.

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