Open AccessA limited sampling strategy for estimation of the area under the curve (0 to 8 hours) of mycophenolic acid administered three times daily to liver transplant recipients
Author(s) -
Bernardino Marcos,
L.F. Bouzas,
J. Carlos Tutor
Publication year - 2010
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009734.2010.523801
Subject(s) - medicine , mycophenolic acid , sampling (signal processing) , estimation , mycophenolate , area under the curve , urology , transplantation , surgery , management , filter (signal processing) , computer science , economics , computer vision
Gastrointestinal side-effects caused by mycophenolic acid (MPA) are frequent in liver transplant recipients, and in these cases a switch from two to three daily doses is usually recommended. However, a limited sampling strategy for the estimation of MPA area under the curve from 0 to 8 hours (AUC(0-8h)) has not been made.