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Background:  Many heat patches are known, based on a reaction system comprising iron, carbon, vermiculite, potassium chloride, and water. The heat release from the inorganic oxidation of iron is initiated by exposure to oxygen, such as when the patch is removed from the plastic pouch. Severe burns have occurred when these products are used in conjunction with a heat source such as an analgesic heating patches. Objectives: Concepts in Cutaneous toxicity is to determine the potential of heat patches to promote skin sensitization reactions after repeated applications using the although modified Buehler test protocols were used.  Buehler tests were conducted according to OECD guideline #406 using a multiple-dose design and test results were analyzed using a standard logistic dose-response model. Contact dermal sensitization is an immunological process where the host animal, through repeated skin exposure, acquires a specific allergic sensitivity to heat patches. In the modified Buehler model,   using rabbit contact dermal sensitivity is manifested as increased erythema and /or oedema.  Materials and Methods: In the modified using rabbits Buehler protocol test, the induction group at 24 hours after challenge patch removal and again at 48 hours after patch removal with induction patches (1 patch per week). Two weeks after induction the animals are challenged by closed-patch tests to the rabbit's abdominal wall skin for 6h. All tests in the Buehler assay are performed on restrained animal we investigated the feasibility of using heat patches topically applied to abdominal wall skin (rabbits) clipped free of hair by experimental induction and challenge phases as an acceptable method to assess the potential of a occluded exposure to analgesic heat patches to promote skin sensitization reaction. Ressuts: Depending on collected tables data of challenge  versus  rechallenge weeks (1,2,7) senisation reaction results ,shown  that  the potential cutaneous toxicity of the test  heat patches was non –irritating   to week sensitizer category using rabbit's abdominal wall skin-topical exposure in the test animals by the modified  Buehler test. Conclusion: The safety use of topical occluded heat patches as pain analgesic if the end-user follows the instruction of application properly.

Skin Sensitization Assay of Topical Occluded Heat Patches by Modified Buehler Method Using Rabbits