Formulation and evaluation of Acyclovir microparticles for Ocular Delivery | Zendy

Shekhar Singh | Zendy; Anil Middha | Zendy; Randhir Singh | Zendy

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Formulation and evaluation of Acyclovir microparticles for Ocular Delivery

Author(s) -

Shekhar Singh,

Anil Middha,

Randhir Singh

Publication year - 2016

Publication title -

indian journal of pharmaceutical and biological research

Language(s) - English

Resource type - Journals

ISSN - 2320-9267

DOI - 10.30750/ijpbr.4.2.6

Subject(s) - microparticle , zeta potential , ethyl cellulose , drug delivery , drug , chromatography , chemistry , phosphate buffered saline , pharmacology , nanotechnology , materials science , medicine , chemical engineering , organic chemistry , nanoparticle , polymer , engineering

The objective of the present work was to formulate and evaluate microparticles of Acyclovir and produced sustained drug delivery for ocular delivery. In this 9 batches(A1-C3) of acyclovir microparticle was prepared with ethyl cellulose, PVA and other ingredients by solvent evaporation technique. The prepared microparticles were evaluated for different parameters i.e % Drug yield, % Drug entrapment, Surface morphology, Zeta potential and in-vitro drug release for 24hrs in phosphate buffer 7.4 and simulated tear fluid. The best batch was performed stability studies for 6 months. The research concluded that Acyclovir microparticles could be a alternative for conventional dosage formand other phytochemical in herbs.

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