Development of CelecoxibTransfersomal gel for the Treatment of Rheumatoid Arthritis | Zendy

P Preeti | Zendy; Murugesan Senthil Kumar | Zendy

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Development of CelecoxibTransfersomal gel for the Treatment of Rheumatoid Arthritis

Author(s) -

P Preeti,

Murugesan Senthil Kumar

Publication year - 2014

Publication title -

indian journal of pharmaceutical and biological research

Language(s) - English

Resource type - Journals

ISSN - 2320-9267

DOI - 10.30750/ijpbr.2.2.2

Subject(s) - transdermal , celecoxib , rheumatoid arthritis , in vivo , permeation , chemistry , ex vivo , pharmacology , vesicle , niosome , drug , drug delivery , chromatography , in vitro , medicine , biochemistry , immunology , organic chemistry , microbiology and biotechnology , membrane , biology

The aim of the present study was to investigate the potential of Transfersomal gel formulations for transdermal delivery of Celecoxib and to evaluate the effect of concentration of Soya PC and Sodium deoxycholate. Transfersomal vesicles containing Soya PC mixed with Sodium deoxycholate and Celecoxib were prepared by conventional rotatory evaporation (Film hydration method) and characterized for vario us parameters including vesicle shape, size and size distribution, surface morphology, ent rapment efficiency, in-vitro and ex-vivo drug release and in-vivo anti-inflammatory activity. Vesicles were also eva luated for skin irritation study and permeation studies.Results of all the studies suggested that CelecoxibTransfersomal gel formulation was therapeutically effective drug delivery system for treatment of Rheumatoid Arthritis.

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