Antinociceptive and cytotoxic potential of ethanolic extract of Delonix regia (Leaves)

This study investigated the antinociceptive and cytotoxic effects of alcoholic extract ofDelonix regia Leaves in rodents. Antinociceptive activities were done using paw licking andwrithing tests. The extract was used at dose of 200 and 400 mg/kg per orally as compared toStandard drug Diclofenac-Na 100 mg/kg bw in Swiss albino mice of body weight 25-30 g.The cytotoxic activity was determined by the Brine Shrimp lethality bioassay. The alcoholicextract showed very highly significant effect in formalin test (p less than 0.01). Also had the highestanalgesia (p less than 0.001) in the acetic acid-induced writhing model as well. The extract possesseda good in vitro cytotoxic activity (LC50=4.06 µg/ml). The results suggested that Delonix regiaLeaves extract has a suitable antinociceptive effect as well as cytotoxic potential.