Synthesis, Characterization and Screening of Anti-tubercular activity of 2, 5-Disubstituted-1, 3, 4-Oxadiazole | Zendy

Alex Martín | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synthesis, Characterization and Screening of Anti-tubercular activity of 2, 5-Disubstituted-1, 3, 4-Oxadiazole

Author(s) -

Alex Martín

Publication year - 2013

Publication title -

indian journal of pharmaceutical and biological research

Language(s) - English

Resource type - Journals

ISSN - 2320-9267

DOI - 10.30750/ijpbr.1.3.3

Subject(s) - hydrazine (antidepressant) , hydrazide , hydrate , chemistry , oxadiazole , ethanol , elemental analysis , microwave irradiation , furan , spectral analysis , organic chemistry , nuclear chemistry , medicinal chemistry , catalysis , chromatography , spectroscopy , physics , quantum mechanics

The synthesis of 2-furyl-5-(substituted)-1,3,4-oxadiazoles was carried out by microwaveirradiation of 2-furoic acid and ethanol followed by subsequent hydrazinolysis with hydrazinehydrate. Finally furan-2-acid hydrazide was treated with appropriate carboxylic acid in thepresence of phosphorous oxychloride to produce title compounds. The structures of the newlysynthesized compounds were established on the basis of spectral analysis such as IR, H1NMRand Mass spectral data. The synthesized compounds were screened for their anti-tubercularactivity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research