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Polymerase Chain Reaction Background and Objectives: Multidrug-resistant (MDR) enterococci cause many problems for physicians and infection control specialists in the recent years. Hence, by identification of antibiotic resistance patterns of enterococci in different geographical regions, an appropriate strategy can be developed to prevent bacterial antibiotic resistance and provide effective treatments. The current study aimed at identifying enterococci via molecular methods and evaluating multi-drug resistance patterns in Enterococcus species isolated from nosocomial samples of some hospitals in Tehran, Iran. Material and Methods: The current study was conducted on 300 nosocomial samples from different hospitals in Tehran, Iran. The identified Enterococcus species of E. faecalis and E. faecium were isolated via biochemical testing and confirmed using polymerase chain reaction (PCR). The antibiotic resistance pattern was determined using the disc diffusion method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: The highest antibiotic resistance was observed against quinupristindalfopristin, tetracycline, and erythromycin. Minimum inhibitory concentration (MIC) of vancomycin against the isolated antibiotic resistant Enterococcus spp. was ≤ 256 μg/mL. According to the results of the current study, 69.6% of E. faecalis and 80% of E. faecium isolates showed multi-drug resistance. Conclusion: Increase of antibiotic resistant bacteria, especially MDR species, is a severe health threatening problem worldwide. The increase of MDR bacteria limited the therapeutic solutions to the patients with enterococcal infection, increased treatment costs, and led to transmission of resistant genes among bacteria. It is highly important to find antibiotic resistant patterns to compile guidelines for infectious diseases. Article Info

modern medical laboratory journal

Molecular Identification of Pathogenic Enterococci and Evaluation of Multi-drug Resistance in Enterococcus Species Isolated From Clinical samples of Some Hospitals in Tehran, Iran