A Rare Case of Mortality Following Heparin-induced Necrotizing Skin Lesions as Thromboprophylaxis After Total Abdominal Hysterectomy

Anticoagulant therapy has been used for the prevention and treatment of deep vein thrombosis and pulmonary embolism (1) after major surgery (2, 3) . Heparin-induced skin necrosis is a rare complication (4), which was first observed in 1973 (5) and their frequency is estimated to be less than 0.2% (6) . It usually happens about 8-11 days after heparin therapy. It could also occur sooner if the patient has any history of the previous reaction to Heparin administration (4) .