The Effect of Melissa officinalis Extract on Streptozotocin-Induced Diabetes in Rats: A Stereological Study on Pancreatic Islets and Beta-cells | Zendy

Soheil AshkaniEsfahani | Zendy; Alireza Ebrahimi | Zendy; Maryam Bahmani-Jahromi | Zendy; Elham Nadimi | Zendy; Hossein Arabzadeh | Zendy; Mohammad Hassan Jalalpour | Zendy; Ali Ghasemnezhad | Zendy; Sedigheh Ebrahimi | Zendy

Open Access

The Effect of Melissa officinalis Extract on Streptozotocin-Induced Diabetes in Rats: A Stereological Study on Pancreatic Islets and Beta-cells

Author(s) -

Soheil AshkaniEsfahani,

Alireza Ebrahimi,

Maryam Bahmani-Jahromi,

Elham Nadimi,

Hossein Arabzadeh,

Mohammad Hassan Jalalpour,

Ali Ghasemnezhad,

Sedigheh Ebrahimi

Publication year - 2020

Publication title -

journal of advances in medical and biomedical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.113

H-Index - 12

ISSN - 2676-6264

DOI - 10.30699/jambs.29.132.34

Subject(s) - streptozotocin , melissa officinalis , diabetes mellitus , pancreatic islets , beta cell , stereology , beta (programming language) , islet , endocrinology , medicine , traditional medicine , computer science , programming language

Materials & Methods: To induce diabetes mellitus (DM) in rats, STZ (60 mg/kg) was injected intraperitoneally. Forty eight rats were randomly divided into four groups: control 1 (C1) consisted of healthy rats, control 2 (C2) consisted of non-treated diabetic rats, and treatment groups 1 and 2 (T1, T2) were the diabetics orally treated with 150 and 300 mg/kg MO for 14 days, respectively. After euthanizing the animals, their pancreases were extracted and sent for stereological evaluations. Volume density (Vv; %), the absolute volume of the islets (mm3), numerical density of beta cells (Nv; per mm3), and their total number (×106), were measured. P-value<0.05 was considered as statistically significant.

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