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Materials & Methods: To induce diabetes mellitus (DM) in rats, STZ (60 mg/kg) was injected intraperitoneally. Forty eight rats were randomly divided into four groups: control 1 (C1) consisted of healthy rats, control 2 (C2) consisted of non-treated diabetic rats, and treatment groups 1 and 2 (T1, T2) were the diabetics orally treated with 150 and 300 mg/kg MO for 14 days, respectively. After euthanizing the animals, their pancreases were extracted and sent for stereological evaluations. Volume density (Vv; %), the absolute volume of the islets (mm3), numerical density of beta cells (Nv; per mm3), and their total number (×106), were measured. P-value<0.05 was considered as statistically significant.

The Effect of Melissa officinalis Extract on Streptozotocin-Induced Diabetes in Rats: A Stereological Study on Pancreatic Islets and Beta-cells