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Background: Due to the increase in gastrointestinal diseases, the use of low-potency herbal medicines for treatment has increased. The synergistic effect of Glycyrrhiza glabra and Astragalus gossypinus on the healing of gastric ulcers is the aim of this study. Materials & Methods: The both plants were harvested and extracted. The most appropriate dose for the use of G. glabra extract in experiments, 200 mg/kg /day, was determined by performing writing tests and carrageenan. Then, to create of gastric ulcer in rats, rats were gavaged for 3 days with a dose of 200 mg/kg/day of dissolved aspirin in 1% Carbocyte methylcellulose. The groups were treated with dose 200 mg/kg/day (Concentration of 0.363 mg/mL) of both extracts and distilled water for 14 days. Four gastric ulcer rat groups, respectively, received both extracts, G. glabra extract, omeprazole and distilled water as a positive control group, and the fifth group or negative control group Without gastric ulcer received distilled water. After the treatment period, the rats were described and ulcers were examined under microscopic and pathological examination. Results: Both extracts together (200 mg/kg/day) reduced the wound coefficient significantly (P<0.01) compared to the two control groups. The percentage of wound healing was increased than the positive control group (omeprazole) 90.27% and the negative control group (distilled water) 91.53%. Pathologic examination confirms microscopic findings. Conclusion: The statistical evaluation of the results shows that the effects of gastric ulcer as a result of the consumption of G. glabra are very low and valuable (P<0.01). Also, the use of both extracts together is not synergistic.

Investigating the Effect of Synergistic Glycyrrhiza glabra and Astraglus gossypinus on Improvement of Gastrointestinal Wound in Rats