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IJMM 2018; 12(4): 260-268 Background and Aims: The virulence plasmid of the Gram negative pathogen Shigella generates many virulence factors within the Ipa-mxi-spa region. Shigella spreads via fecal-oral and person-to-person transmission which causes human bloody diarrhea. In Asia alone, it is estimated that there are 125 million infections and 14,000 deaths due to shigellosis annually. IpaB is essential for Shigella infection and pathogenicity.

The Study of the Stable Expression of IpaB, the Virulence Factor in Shigella Sonnei, in Terms of Simultaneous Expression of Chaperone IpgC