The Effect of Oncolytic Reovirus Infection on Nitric Oxide Secretion and Induction of Apoptosis in Adipose Tissue-Derived Mesenchymal Stem Cells | Zendy

Razieh Sadat Banijamali | Zendy; Hoorieh Soleimanjahi | Zendy; Sara Soudi | Zendy; Hesam Karimi | Zendy

Open Access

The Effect of Oncolytic Reovirus Infection on Nitric Oxide Secretion and Induction of Apoptosis in Adipose Tissue-Derived Mesenchymal Stem Cells

Author(s) -

Razieh Sadat Banijamali,

Hoorieh Soleimanjahi,

Sara Soudi,

Hesam Karimi

Publication year - 2018

Publication title -

iranian journal of medical microbiology

Language(s) - English

Resource type - Journals

eISSN - 2345-4342

pISSN - 1735-8612

DOI - 10.30699/ijmm.12.3.218

Subject(s) - mesenchymal stem cell , oncolytic virus , adipose tissue , nitric oxide , apoptosis , secretion , microbiology and biotechnology , biology , cancer research , medicine , tumor cells , biochemistry

IJMM 2018; 12(3): 218-229 Background and Aims: Oncolytic viruses (OVs) are a new approach in treatment of cancer. Antitumor efficacy of OVs were limited due to insufficient and non-specific viral delivery to tumor sites. To overcome this issue, mesenchymal stem cells (MSCs) were used for their ability to specifically homing into tumors. The main aim of this study was to use MSCs as carriers and investigate the effect of oncolytic reovirus infection in MSCs, induction of apoptosis, nitric oxide (NO) secretion and their effects for selectively killing tumor cells, to use in future.

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