Diagnostic approach of an IgM monoclonal gammopathy and clinical importance of gene MYD88 L265P mutation | Zendy

N Cilla | Zendy; Marie Vercruyssen | Zendy; Lieveke Ameye | Zendy; M Paesmans | Zendy; Alexandre de Wind | Zendy; Pierre Heimann | Zendy; Nathalie Meuleman | Zendy; Dominique Bron | Zendy

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Diagnostic approach of an IgM monoclonal gammopathy and clinical importance of gene MYD88 L265P mutation

Author(s) -

N Cilla,

Marie Vercruyssen,

Lieveke Ameye,

M Paesmans,

Alexandre de Wind,

Pierre Heimann,

Nathalie Meuleman,

Dominique Bron

Publication year - 2018

Publication title -

revue medicale de bruxelles

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.118

H-Index - 13

eISSN - 2795-8558

pISSN - 0035-3639

DOI - 10.30637/2018.17-090

Subject(s) - waldenstrom macroglobulinemia , lymphoplasmacytic lymphoma , monoclonal gammopathy of undetermined significance , macroglobulinemia , lymphoma , medicine , monoclonal , multiple myeloma , gammopathy , gastroenterology , mutation , pathology , immunology , monoclonal antibody , biology , gene , antibody , genetics

An IgM monoclonal gammopathy points to a diagnosis of Waldenstrom's Macroglobulinemia. Other B lymphoproliferatives disorders should be ruled out but the limits are sometimes difficult to define. The discovery of the L265P mutation of the MYD88 gene simplified potentially the situation.

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