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Objective: to evaluate the effectiveness and safety of policresulen against estriol and vaginal lubricant in the treatment of menopausal genitourinary syndrome in women from Armenia (Quindío, Colombia). Materials and methods: in women diagnosed with genitourinary menopausal syndrome, a randomized, three-blind, controlled clinical trial was conducted. ree groups were assigned (estriol, n = 86, vaginal lubricant, n = 83 and policresulen, n = 82). e main indicator parameter of effectiveness was the elevation of the vaginal health index (ISV) score, improvement in sexual function according to the Abbreviated Female Sexual Function Index-6 (IFSFA-6), percentage of improvement in symptoms and incidence of adverse effects. Results: the effectiveness was greater with the use of estriol, followed by policresulen and less with the vaginal lubricant (92.82%, 75.69% and 63.74%, respectively, p = 0.012); Differences were also found in the improvement of sexual function, according Franklin José Espitia de la Hoz. Efectividad y seguridad del policresuleno en el tratamiento del síndrome genitourinario de la menopausia. ... PDF generado a partir de XML-JATS4R por Redalyc Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto to IFSFA-6 scores [29.29 ± 6.23 (estriol), 28.66 ± 6.12 (policresulen) and 25.38 ± 6.27 (vaginal lubricant), p = 0.021], with differences in the percentage of both improvement in symptoms and in the presentation of adverse effects (p = 0.001). Conclusions: polycresullen has a significant effectiveness in the treatment of genitourinary syndrome of menopause, superior compared to vaginal lubricant, but inferior when compared to estriol. e presence of adverse effects is evident, greater with estriol, followed by policresulen and then vaginal lubricant, without questioning the remarkable safety profile of polyresulin.

Efectividad y seguridad del policresuleno en el tratamiento del síndrome genitourinario de la menopausia. Estudio controlado y aleatorizado