Synthesis of (E)-(4-(Aryl)phenyl)(3-(2-(1-phenyl-3-(thiophen-2-yl)-1Hpyrazol-4-yl)vinyl)benzofuran-2-yl)methanones by Claisen Schmidt-Suzuki Cross Coupling and their Antibacterial and Antifungal Activity | Zendy

D. Ashok | Zendy; M. Ziauddin | Zendy; Bommidi Vijaya Lakshmi | Zendy; M. Sarasija | Zendy

Open Access

Synthesis of (E)-(4-(Aryl)phenyl)(3-(2-(1-phenyl-3-(thiophen-2-yl)-1Hpyrazol-4-yl)vinyl)benzofuran-2-yl)methanones by Claisen Schmidt-Suzuki Cross Coupling and their Antibacterial and Antifungal Activity

Author(s) -

D. Ashok,

M. Ziauddin,

Bommidi Vijaya Lakshmi,

M. Sarasija

Publication year - 2017

Publication title -

journal of the mexican chemical society

Language(s) - English

Resource type - Journals

ISSN - 2594-0317

DOI - 10.29356/jmcs.v61i3.342

Subject(s) - chemistry , aspergillus flavus , benzofuran , aspergillus niger , aryl , stereochemistry , antibacterial activity , fusarium oxysporum , medicinal chemistry , nuclear chemistry , organic chemistry , alkyl , bacteria , biology , biochemistry , botany , food science , genetics

A series of ten novel ( E )-(4-(aryl)phenyl)(3-(2-(1-phenyl-3- (thiophen-2-yl)-1 H -pyrazol-4-yl)vinyl)benzofuran-2-yl)methanones ( 7a-j ) derivatives were prepared by traditional Claisen-Schmidt and Suzuki cross-coupling reaction under conventional and microwave irradiation conditions. The structures of all the newly synthesized compounds were established on the basis of FTIR, 1 H NMR, 13 C NMR, mass spectral data and elemental analysis. The products were assayed for their in vitro antibacterial activity against different types of bacterial strains. Further the antifungal activity was examined by inhibitory action against three fungal strains such as Aspergillus niger , Aspergillus flavus and Fusarium oxysporum .

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