Reaction of o-Aminobenzamides with Dialkyl Carbonates and Ionic Liquids: A Novel one-pot, High-yield, Microwave-assisted Synthesis of 1-Alkylquinazoline-2,4-diones | Zendy

Leticia Guerrero R. | Zendy; Ignacio A. Rivero | Zendy

Open Access

Reaction of o-Aminobenzamides with Dialkyl Carbonates and Ionic Liquids: A Novel one-pot, High-yield, Microwave-assisted Synthesis of 1-Alkylquinazoline-2,4-diones

Author(s) -

Leticia Guerrero R.,

Ignacio A. Rivero

Publication year - 2017

Publication title -

journal of the mexican chemical society

Language(s) - English

Resource type - Journals

ISSN - 2594-0317

DOI - 10.29356/jmcs.v56i2.322

Subject(s) - yield (engineering) , alkylation , microwave irradiation , ionic bonding , ionic liquid , chemistry , microwave , combinatorial chemistry , nuclear chemistry , medicinal chemistry , organic chemistry , materials science , ion , catalysis , computer science , telecommunications , metallurgy

A simple and efficient methodology for the synthesis of 1-alkyl-2,4-(1H,3H)-quinazolinediones from o-aminobenzamides has been developed. The novel one-pot cyclization-alkylation reactions are easier and faster than any other reported protocols and resulted in excellent yields (96-98%) and high purities, making this methodology suitable for library synthesis in drug discovery efforts. By applying microwave irradiation at 130 °C and in the presence of ionic liquids, dimethyl or diethyl carbonates simultaneously act as carbonylating

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