Antigiardial Activity of Cupania dentata Bark and its Constituents | Zendy

Ignacio Hernández-Chávez | Zendy; Luis W. TorresTapia | Zendy; Paulino Simá-Polanco | Zendy; Roberto CedilloRivera | Zendy; Rosa MooPuc | Zendy; Sergio R. PerazaSánchez | Zendy

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Antigiardial Activity of Cupania dentata Bark and its Constituents

Author(s) -

Ignacio Hernández-Chávez,

Luis W. TorresTapia,

Paulino Simá-Polanco,

Roberto CedilloRivera,

Rosa MooPuc,

Sergio R. PerazaSánchez

Publication year - 2017

Publication title -

journal of the mexican chemical society

Language(s) - English

Resource type - Journals

ISSN - 2594-0317

DOI - 10.29356/jmcs.v56i2.305

Subject(s) - chemistry , scopoletin , phytochemical , bark (sound) , traditional medicine , biology , biochemistry , medicine , ecology , alternative medicine , pathology

The MeOH extract of Cupania dentata bark (Sapindaceae) as well as its hexane, CH2Cl2, EtOAc, and BuOH fractions showed high activity against Giardia lamblia trophozoites (IC50 = 2.12-9.52 µg/mL). The phytochemical study of fractions resulted in the isolation of taraxerone (1), taraxerol (2), scopoletin (3), and two mixtures of steroidal compounds. Taraxerone was the metabolite with the highest giardicidal activity (IC50 = 11.33 µg/mL).

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