SYNTHESIS , CHARACTERIZATION AND STUDY BIOLOGICAL ACTIVITY SOME NEW DERIVATIVES AMIDE AND PYRAZOLE –PYRAZOLINE OF STEROID ANALOGS . | Zendy

Nabeel A.A. AL-Rida | Zendy; Ali M. Farhan | Zendy

Open Access

SYNTHESIS , CHARACTERIZATION AND STUDY BIOLOGICAL ACTIVITY SOME NEW DERIVATIVES AMIDE AND PYRAZOLE –PYRAZOLINE OF STEROID ANALOGS .

Author(s) -

Nabeel A.A. AL-Rida,

Ali M. Farhan

Publication year - 2019

Publication title -

al-qadisiyah journal of pure science

Language(s) - English

Resource type - Journals

eISSN - 2411-3514

pISSN - 1997-2490

DOI - 10.29350/jops.2019.24.3.971

Subject(s) - steroid , pyrazole , chemistry , pyrazoline , hydrazide , amide , thio , heteronuclear single quantum coherence spectroscopy , hydrazine (antidepressant) , stereochemistry , hydrate , nuclear magnetic resonance spectroscopy , organic chemistry , biochemistry , hormone

The number of steroids and their derivatives possess divers pharmacological activities as drugs for the treatment of a large number of diseases so in this work was suggested prepared two series amides and pyrazoles of steroid analogs ( methyl((5-pregnant-3β,17-diol-15-yl) thio) propanoate) . Amides derivatives ( 6 - 9 ) prepared directionally after treated the steroid analogs with primary amine substituted in basic medium . Carbo hydrazide steroid derivative (10 ) was obtained by treated steroid analogs with hydrazine hydrate , this compound use as intermediate for synthesis Pyrazolin (13 ) as well as Pyrazole (14) . All the newly synthesized compounds have been identified by IR, 1H NMR, 13CNMR, 2D-NMR ( HMBC , HSQC ) and C.H.N Analysis

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