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A case control study was conducted on 49 subjects 29 of them with chronic renal disease and 20 subjects as control with age range between (45-75) years were investigated to determine the correlation of salivary and serum cystatin, urea and creatinine to assess their significance in the diagnoses of patients with chronic renal disease. The results indicated that the level of salivary cystatin was significantly (P ≤ 0.05) elevated in chronic renal disease (292.517±37.19 ng/ml) as compared to control (144.45±22.963 ng/ml). The level of serum cystatin was significantly (P ≤ 0.05) elevated in chronic renal disease (498.414±59.091 ng/ml) as compared to control (391.60±49.488ng/ml). The level of serum creatinine was significantly (P ≤ 0.05) elevated in chronic renal disease (4.369±0.799 mg/dl) as compared to control (1.007± 0.180 mg/dl). The level of urea was significantly (P ≤ 0.05) elevated in chronic renal disease (56.138±5.908 mg/dl) as compared to control (31.80 ± 5.176 mg/dl). From all the above results, we can conclude that salivary cystatin can be considered as a better biochemical marker for renal function compared to serum cystatin in chronic renal disease.

Salivary Cystatin C as a Biochemical Marker for Chronic Renal Failure