Application of Differential Scanning Calorimetry and Fourier Transform Infrared Spectroscopy to the Study of Metoprolol-Excipient and Lisinopril-Excipient Compatibility | Zendy

Hale Seçi̇lmi̇ş Canbay | Zendy; Mahmut Doğantürk | Zendy

Open Access

Application of Differential Scanning Calorimetry and Fourier Transform Infrared Spectroscopy to the Study of Metoprolol-Excipient and Lisinopril-Excipient Compatibility

Author(s) -

Hale Seçi̇lmi̇ş Canbay,

Mahmut Doğantürk

Publication year - 2018

Publication title -

eurasian journal of analytical chemistry

Language(s) - English

Resource type - Journals

ISSN - 1306-3057

DOI - 10.29333/ejac/92739

Subject(s) - excipient , differential scanning calorimetry , fourier transform infrared spectroscopy , lisinopril , materials science , fourier transform , compatibility (geochemistry) , metoprolol , chemistry , analytical chemistry (journal) , chromatography , chemical engineering , mathematics , composite material , medicine , engineering , thermodynamics , physics , mathematical analysis , radiology , blood pressure , cardiology , angiotensin converting enzyme

Studies of pharmaceutical drug/active pharmaceutical ingredient (API) compatibility represent an important phase in the design or development of new formulation stage and drug delivery systems. Excipients in the formulations are influenced by the chemical nature, stability, manufacturability, drug bioavailability or delivery of the drug to the patient. Differential scanning calorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FTIR) were used as an analytical screening technique for defining the conformity, quality, ability, compatibility of metoprolol and lisinopril with some recently employed pharmaceutical excipients.

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