Interactive effects of reducing exercise intensity and Adiantum capillus veneris extract on remodeling and modulation of pulmonary apoptotic indices in the rats exposed to the hypoxia.

Background and Aim: Apoptosis is a type of programmed cell death occurring by a series of intercellular messages which is associated with tissue structure remodeling. The purpose of the present study was to investigate the interactive effects of reducing exercise intensity and Adiantum capillus veneris extract on remodeling and modulation of pulmonary apoptotic indices of the rats exposed to the hypoxia. Material and Methods: This study included 16 male Wistar rats. After 6 weeks of high intensity interval training, the rats were kept in a hypoxic environment for 3 weeks. In hypoxic environment, half of the rats performed interval training and taper and received 500 mg/kg of Adiantum capillus veneris extract. Finally, lung tissue was extracted for immunohistochemical and stereology studies. Results: 3 weeks of simultaneous exercise intensity and taper and Adiantum capillus veneris extract consumption in the hypoxia group led to decreased Bax/Bcl-2 ratio(p<0.05) and nematocytes-2 population (p>0.05), compared to increased alveolar nematocytes-1 population in the hypoxia group (p<0.05 ). Conclusion: The results of this study showed that simultaneous use of exercise intensity and taper and consumption of Adiantum capillus veneris extract is effective in decreasing apoptosis and remodeling of Alveolar epithelial cells after high intensity interval training and exposure to hypoxia.