Importance of CNOT8 Deadenylase Subunit in DNA Damage Responses Following Ionizing Radiation (IR) | Zendy

Samira Eskandarian | Zendy; Roger J.A. Grand | Zendy; Shiva Irani | Zendy; Mohsen Saeedi | Zendy; Reza Mirfakhraie | Zendy

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Importance of CNOT8 Deadenylase Subunit in DNA Damage Responses Following Ionizing Radiation (IR)

Author(s) -

Samira Eskandarian,

Roger J.A. Grand,

Shiva Irani,

Mohsen Saeedi,

Reza Mirfakhraie

Publication year - 2020

Publication title -

reports of biochemistry and molecular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.467

H-Index - 8

ISSN - 2322-3480

DOI - 10.29252/rbmb.9.2.163

Subject(s) - ionizing radiation , dna damage , dna , protein subunit , genetics , biology , computational biology , irradiation , physics , gene , nuclear physics

The Ccr4-Not protein complex (CNOT complex) is a key regulator of gene expression in eukaryotic cells. Ccr4-Not Complex is composed of at least nine conserved subunits in mammalian cells with two main enzymatic activities. CNOT8 is a subunit of the complex with deadenylase activity that interacts transiently with the CNOT6 or CNOT6L subunits. Here, we focused on the role of the human CNOT8 subunit in the DNA damage response (DDR).

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