Assessment of GSTO1 (A140D) and GSTO2 (N142D) Gene Polymorphisms in Iranian Women with Polycystic Ovarian Syndrome | Zendy

Seyyed Shahram Miraghaee | Zendy; Maryam Sohrabi | Zendy; Cyrus Jalili | Zendy; Fariborz Bahrehmand | Zendy

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Assessment of GSTO1 (A140D) and GSTO2 (N142D) Gene Polymorphisms in Iranian Women with Polycystic Ovarian Syndrome

Author(s) -

Seyyed Shahram Miraghaee,

Maryam Sohrabi,

Cyrus Jalili,

Fariborz Bahrehmand

Publication year - 2020

Publication title -

reports of biochemistry and molecular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.467

H-Index - 8

ISSN - 2322-3480

DOI - 10.29252/rbmb.9.1.8

Subject(s) - genotype , allele , polycystic ovary , gene , biology , genetics , medicine , odds ratio , genotype frequency , allele frequency , endocrinology , insulin resistance , insulin

Glutathione S-transferases (GSTs) protect cells from oxidative stress (OS). In humans, the GST omega class contains two expressed genes, GSTO1 and GSTO2 . Because OS is involved in the pathogenesis of polycystic ovary syndrome (PCOS), the aim of this study was to investigate the relationship between GSTO1 A140D (rs4925) and GSTO2 N142D (rs156697) polymorphisms in PCOS patients.

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