The Relationship between KIT Copy Number Variation, Protein Expression, and Angiogenesis in Sporadic Breast Cancer | Zendy

Maryam Rahimi | Zendy; Farkhondeh Behjati | Zendy; Hamid Reza Khorram Khorshid | Zendy; Masoud Karimlou | Zendy; Elahe Keyhani | Zendy

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The Relationship between KIT Copy Number Variation, Protein Expression, and Angiogenesis in Sporadic Breast Cancer

Author(s) -

Maryam Rahimi,

Farkhondeh Behjati,

Hamid Reza Khorram Khorshid,

Masoud Karimlou,

Elahe Keyhani

Publication year - 2020

Publication title -

reports of biochemistry and molecular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.467

H-Index - 8

ISSN - 2322-3480

DOI - 10.29252/rbmb.9.1.40

Subject(s) - angiogenesis , breast cancer , cancer research , immunohistochemistry , carcinogenesis , cd34 , tumor progression , cancer , biology , pathology , medicine , stem cell , genetics

KIT is a protooncogene that encodes for the KIT oncoprotein, which is a transmembrane tyrosine kinase growth factor receptor that holds a critical role in a variety of normal physiological and pathological processes including angiogenesis. KIT has been shown to be involved in tumorigenesis, contributing to the development of gastrointestinal carcinoma and leukemia. A link between KIT overexpression and breast cancer development has previously been reported. In the current study, we explored KIT gene expression and exonic copy number variants (CNV) and the relationship with angiogenesis (CD34) and the clinicopathological features of breast cancer.

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